Figure 2:

Results of noninferiority trials, noninferiority margins of the trials, and preserved-effects reference noninferiority margins using relative risk. The confidence intervals resemble the effects of test drug –active comparator (negative treatment effect is desirable). Point-of-no-difference between test drug and enoxaparin is 1.000. CI = confidence interval, M1 = effect of active control versus placebo, M2 = largest clinically acceptable difference between the test drug and the active control, RR = relative risk. *M2 for 67% preserved effect. †M2 for 50% preserved effect. ‡M1.