Table A2.

Identity and annotations of A. fumigatus histidine kinase receptors.

Annotation	ORF	Accession number	No. of transmembrane domains	Putative conserved domains	Putative group no.
CHROMOSOME 2
Sensor histidine kinase/response regulator TcsB/Sln1	AFUA_2G00660	XP_001481640.1	4	HiskA (Phospho-acceptor) domain Histidine kinase-, DNA gyrase B- and HSP90-like ATPase Histidine kinase-like ATPases cheY-homologous receiver domain	6
Two-component osmosensing histidine kinase (Bos1)-TcsC	AFUA_2G03560	XP_749489.1	1	Multiple HAMP domains His kinase A (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	3
CHROMOSOME 3
Sensor histidine kinase/response regulator	AFUA_3G07130	XP_754893.1	3	HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	7
Sensor histidine kinase/response regulator	AFUA_3G12530	XP_754368.1	2	PAS domain HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	5
Sensor histidine kinase/response regulator	AFUA_3G12550	XP_754366.1	9	Serine/threonine kinase domain AAA ATPase domain GAF domain HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	10
CHROMOSOME 4
Sensor histidine kinase/response regulator	AFUA_4G00320	XP_746424.2	2	GAF domain HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	2
Sensor histidine kinase/response regulator	AFUA_4G00660	XP_746390.1	1	GAF domain HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	2
Sensor histidine kinase/response regulator	AFUA_4G02900	XP_746476.1	2	GAF domain Phytochrome region HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	8
Sensor histidine kinase/response regulator	AFUA_4G01020	XP_746355.1	3	GAF domain HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	2
Sensor histidine kinase/response regulator	AFUA_4G07400	XP_752086.2	0	Histidine kinase-like ATPases cheY-homologous receiver domain	7
CHROMOSOME 6
Sensor histidine kinase/response regulator Fos-1/TcsA	AFUA_6G10240	XP_750913.1	1	PAS domain HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	5
CHROMOSOME 8
Sensor histidine kinase/response regulator	AFUA_8G06140	XP_747415.2	2	HiskA (Phospho-acceptor) domain Histidine kinase-like ATPases cheY-homologous receiver domain	7

HiskA, Histidine kinase A; HAMP, Histidine kinases, adenyl cyclases, methyl-accepting chemotaxis protein, phosphatase; PAS, Per—period circadian protein, Arnt—Al receptor nuclear translocator protein, Sim—single minded protein; GAF, presence in cGMP-regulated cyclic nucleotides PDEs, certain adenyl cyclases and the bacterial transcription factor FhlA; AAA, ATPases associated with diverse cellular activities.