. Author manuscript; available in PMC: 2013 Feb 20.

Published in final edited form as: Nat Rev Cancer. 2011 May 26;11(7):493–501. doi: 10.1038/nrc3079

Table 2.

Most Frequent Toxicities Associated with SMO Inhibitors^b

Species and tissue	Effect
Mouse teeth	Reduced ameloblast progenitor population
	Loss of enamel from incisors
Mouse developing bone	Loss of proliferating chondrocytes
	Premature growth plate fusion
	Reduced thickness cortical bone
	Structural abnormalities in joints
Adult Humans	Muscle Spasms
	Dysgeusia (altered taste perception)
	Fatigue
	Alopecia (modest)
	Nausea

Mouse data on HhAntag obtained from^{116, 135} and human data on GDC-0449 obtained from⁶. No dose limiting toxicies were identified in the first reported clinical trial of GDC-0449⁶.