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Induction of skin neoplasia in wild-type, Mek1, and Mek2 mutant mice. Skin-restricted Mek1 knockout mice (Mek1fl/flCre; A) and Mek2 knockout mice (Mek2−/−; B) were subjected to the DMBA/TPA two-stage chemical carcinogenesis protocol. A and B, average number of papillomas per mouse, n = 5. Mice were euthanized at wk 20 due to the large tumor burden. *, P < 0.02.
