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DMBA/TPA treatment induced fewer tumors in Mek1 mutant mice. A, induction of skin tumors in Mek1 mutant mice in response to initiation with DMBA and promotion with TPA. Average number of tumors per mouse, n = 4 to 6. *, P = 0.12. B, columns represent the average numbers and sizes of papillomas ≥1 mm in mice as function of time of TPA promotion. Color scale indicates the sizes of papillomas. Mice were euthanized at wk 20 due to large tumor burden. *, P < 0.02; **, P < 0.001.
