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Skin-restricted Mek1 knockout mice, but not Mek2 knockout mice, are resistant to papilloma formation. Representative images of Mek1fl/fl, Mek1fl/flCre, Mek2+/+, Mek2+/−, and Mek2−/− mice showing the dramatic difference in papilloma number and size at wk 16 (A) and wk 20 (B). C, H&E staining of a portion of a representative papilloma in wild-type (WT), Mek2 knockout (Mek2−/−), and skin-restricted Mek1 knockout mice (Mek1fl/flCre). Original magnification, 5×.
