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. Author manuscript; available in PMC: 2013 Feb 20.

Published in final edited form as: Cancer Res. 2009 Apr 21;69(9):3772–3778. doi: 10.1158/0008-5472.CAN-08-1963

Table 1.

Progression of number and size of tumors in mice subjected to DMBA/TPA treatment

Weeks postinitiation	Genotype	Papilloma size
		≤ 3 mm ± SE	4-7 mm ± SE	≥ 8 mm ± SE
12	Mek1^fl/fl	10.4 ± 1.8	0.6 ± 0.5	0 ± 0
	Mek1^fl/flCre	3.0 ± 0.7	0 ± 0	0 ± 0
	Mek1^fl/+	10.2 ± 0.8	0.8 ± 0.4	0 ± 0
	Mek1^fl/+Cre	6.6 ± 3.8	0 ± 0	0 ± 0
	Mek1^fl/Δ	8.4 ± 8.0	0 ± 0	0 ± 0
	Mek1^fl/ΔCre	3.0 ± 2.4	0 ± 0	0 ± 0
	Mek2^+/+	5.0 ± 0.7	0 ± 0	0 ± 0
	Mek1^+/−	4.2 ± 1.1	0 ± 0	0 ± 0
	Mek2^−/−	5.2 ± 3.5	0 ± 0	0 ± 0
16	Mek1^fl/fl	18.4 ± 2.4	2.8 ± 1.5	0 ± 0
	Mek1^fl/flCre	8.4 ± 1.5	1.0 ± 1.0	0 ± 0
	Mek1^fl/+	15.0 ± 4.8	2.4 ± 2.3	0 ± 0
	Mek1^fl/+Cre	12.6 ± 5.3	2.4 ± 1.1	0 ± 0
	Mek1^fl/Δ	15.8 ± 7.3	2.4 ± 2.8	0 ± 0
	Mek1^fl/ΔCre	8.0 ± 4.0	0.2 ± 0.4	0 ± 0
	Mek2^+/+	9.0 ± 2.0	1.0 ± 0.7	0 ± 0
	Mek1^+/−	8.0 ± 1.4	1.0 ± 1.2	0 ± 0
	Mek2^−/−	12.0 ± 4.0	1.4 ± 1.1	0 ± 0
20	Mek1^fl/fl	18.6 ± 4.2	4.6 ± 1.5	1.2 ± 0.4
	Mek1^fl/flCre	12.0 ± 3.1	1.0 ± 1.4	0 ± 0
	Mek1^fl/+	15.4 ± 4.2	4.2 ± 1.3	1.0 ± 0.7
	Mek1^fl/+Cre	15.4 ± 5.2	4.0 ± 0.7	1.0 ± 0.7
	Mek1^fl/Δ	15.6 ± 5.8	4.2 ± 1.5	1.0 ± 1.0
	Mek1^fl/ΔCre	12.8 ± 5.8	0.2 ± 0.4	0 ± 0
	Mek2^+/+	14.2 ± 3.7	4.0 ± 1.6	1.4 ± 1.3
	Mek1^+/−	15.0 ± 3.5	4.0 ± 1.4	1.0 ± 0.7
	Mek2^−/−	17.0 ± 3.3	3.8 ± 1.3	1.0 ± 1.0