Table 1.
Downregulated genes in post-anchorage-independent growth c-Myc T58A HMECs
| Gene Symbol | Sequence Description | Fold Change |
|---|---|---|
|
| ||
| ANXA3 | Annexin A3 | −26.6 |
| KRT6B | Keratin 6B | −26.4 |
| TNFRSF8 | Tumor necrosis factor receptor superfamily, member 8, transcript variant 1 | −23.4 |
| CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) | −22.1 |
| SPRR1B | Small proline-rich protein 1B (cornifin) | −20.7 |
| FLRT3* | Fibronectin leucine rich transmembrane protein 3, transcript variant 2 | −17.2 |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), transcript variant 3 | −16.3 |
| AMIGO2 | Amphoterin induced gene 2 | −12.6 |
| NRG1* | Neuregulin 1, transcript variant GGF2 | −12.2 |
| ALDH1A3 | Aldehyde dehydrogenase 1 family, member A3 | −12.1 |
| ZBED2 | Zinc finger, BED domain containing 2 | −12.0 |
| PTPRZ1 | Protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | −11.7 |
| NRG1* | Neuregulin 1 (NRG1), transcript variant GGF | −11.2 |
| MIG7 | MIG7, complete cds. | −11.2 |
| DSG3 | Desmoglein 3 (pemphigus vulgaris antigen) | −10.3 |
| ANGPTL4 | Angiopoietin-like 4, transcript variant 1 | −10.0 |
| full-length cDNA clone CS0DJ001YJ05 of T cells (Jurkat cell line) Cot 10 | −9.9 | |
| NEFM | Neurofilament 3 (150kDa medium) | −9.8 |
| CLCA2 | Chloride channel, calcium activated, family member 2 | −9.8 |
| CDKN2B | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2 | −9.7 |
| AOX1 | Aldehyde oxidase 1 | −9.7 |
| FGFBP1 | Heparin-binding growth factor binding protein | −9.7 |
| ABCA12 | ATP-binding cassette, sub-family A, transcript variant 1 | −9.6 |
| SFRP1 | Secreted frizzled-related protein 1 | −9.5 |
| PHACTR3 | Phosphatase and actin regulator 3, transcript variant 1 | −9.5 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | −8.9 |
| LEPREL1 | Leprecan-like 1 | −8.8 |
| MYO5B | cDNA: FLJ21683 fis, clone COL09335 | −8.5 |
| IL18 | Interleukin 18 (interferon-gamma-inducing factor) | −8.5 |
| cDNA FLJ44186 fis, clone THYMU2038797 | −8.2 | |
| cDNA FLJ33320 fis, clone BNGH42007798 | −8.1 | |
| KRT15 | Keratin 15 | −7.9 |
| SERPINB7 | Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 | −7.9 |
| LAMA3 | Laminin, alpha 3, transcript variant 1 | −7.9 |
| FLJ12684 | Hypothetical protein FLJ12684 | −7.7 |
| COL8A1* | Collagen, type VIII, alpha 1, transcript variant 1 | −7.7 |
| SERPINA1 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, transcript variant 2 | −7.6 |
| FAM113B | Hypothetical protein MGC16044 | −7.6 |
| FAM83B | cDNA: FLJ21274 fis, clone COL01781 | −7.5 |
| CD24 | CD24 signal transducer mRNA, complete cds and 3′ region | −7.5 |
| KLK8 | Kallikrein 8 (neuropsin/ovasin), transcript variant 2 | −7.4 |
| NRG1* | Neuregulin 1, transcript variant HRG-beta2 | −7.3 |
| CNN3 | Calponin 3, acidic | −7.3 |
| COL8A1* | mRNA full length insert cDNA clone EUROIMAGE 1913076 | −7.2 |
| TRIM29 | Tripartite motif-containing 29, transcript variant 1 | −7.1 |
| C1ORF116 | Specifically androgen-regulated protein | −7.1 |
| PDPN* | Lung type-I cell membrane-associated glycoprotein, transcript variant 1 | −7.1 |
| CDA | Cytidine deaminase | −6.9 |
| cDNA FLJ39181 fis, clone OCBBF2004235 | −6.6 | |
| KLK5 | Kallikrein 5 | −6.6 |
| FXYD3 | FXYD domain containing ion transport regulator 3, transcript variant 1 | −6.6 |
| LAMB3 | Laminin, beta 3, transcript variant 2 | −6.5 |
| FBN2 | Fibrillin 2 (congenital contractural arachnodactyly) | −6.4 |
| MST1R | Macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | −6.4 |
| KIAA1257 | KIAA1257, mRNA (cDNA clone MGC:35174 IMAGE:5170293), complete cds | −6.3 |
| MAL2 | Mal, T-cell differentiation protein 2 | −6.3 |
| EST384910 MAGE resequences, MAGL Homo sapiens cDNA | −6.3 | |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | −6.3 |
| ANK3 | Ankyrin 3, node of Ranvier (ankyrin G), transcript variant 1 | −6.2 |
| cDNA FLJ36835 fis, clone ASTRO2010996 | −6.2 | |
| EVA1 | Epithelial V-like antigen 1, transcript variant 2 | −6.2 |
| IL21R | Interleukin 21 receptor, transcript variant 2 | −6.1 |
| UPP1 | Uridine phosphorylase 1, transcript variant 2 | −6.1 |
| IGFBP7 | Insulin-like growth factor binding protein 7 | −6.0 |
| ICA1 | Islet cell autoantigen 1, 69kDa, transcript variant 2 | −6.0 |
| PREDICTED: Homo sapiens hypothetical LOC401131, transcript variant 1 (LOC401131) | −6.0 | |
| KRT6E | Keratin 6E | −5.9 |
| Endogenous retrovirus H protease/integrase-derived ORF1, ORF2, and putative envelope protein mRNA, complete cds | −5.9 | |
| FOXA2 | Forkhead box A2, transcript variant 1 | −5.8 |
| DHRS3 | Dehydrogenase/reductase (SDR family) member 3 | −5.8 |
| SCRN1 | Secernin 1 | −5.8 |
| GPR87 | G protein-coupled receptor 87 | −5.8 |
| ADAM19 | A disintegrin and metalloproteinase domain 19 (meltrin beta), transcript variant 2 | −5.8 |
| HIST2H2AA3 | Histone 2, H2aa | −5.7 |
| RRM2 | Ribonucleotide reductase M2 polypeptide | −5.6 |
| FLRT3* | Fibronectin leucine rich transmembrane protein 3, transcript variant 2 | −5.6 |
| CABYR | Calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2), transcript variant 1 | −5.5 |
| ADAM23 | A disintegrin and metalloproteinase domain 23 | −5.5 |
| LETM2 | Hypothetical protein FLJ25409 | −5.5 |
| PDPN* | Podoplanin, transcript variant 2 | −5.4 |
| FGFR2 | Fibroblast growth factor receptor 2, transcript variant 2 | −5.4 |
| MARK1 | MAP/microtubule affinity-regulating kinase 1 | −5.3 |
| STEAP1 | Six transmembrane epithelial antigen of the prostate | −5.3 |
| CLMN | Calmin (calponin-like, transmembrane) | −5.2 |
| CAV1 | Caveolin 1, caveolae protein, 22kDa | −5.2 |
| C10ORF47 | Chromosome 10 open reading frame 47 | −5.2 |
| GSTO2 | Glutathione S-transferase omega 2 | −5.2 |
| XIST | X (inactive)-specific transcript on chromosome X | −5.1 |
| RNF128 | Ring finger protein 128, transcript variant 1 | −5.1 |
| SCN4B | Sodium channel, voltage-gated, type IV, beta | −5.1 |
| TMEM40 | Hypothetical protein FLJ11036 | −5.1 |
| GLS2 | Glutaminase 2 (liver, mitochondrial), nuclear gene encoding mitochondrial protein, transcript variant 1 | −5.0 |
| FAM83A | Family with sequence similarity 83, member A, transcript variant 1 | −5.0 |
| DMD | Dystrophin (muscular dystrophy, Duchenne and Becker types), transcript variant Dp427p2 | −5.0 |
| POPDC3 | Popeye domain containing 3 | −5.0 |
Genes shown have an absolute fold change of five or greater and a p-value<0.05.
*
indicates genes with more than one transcript in the table.