Table 1.

Two-marker logistic model association test results for coronary artery disease

Ch	SNP1	MAF1	SNP2	MAF2	2 df P value	3 df P value	Hap	R2	D′	Pairs	Gene	CAD Link?
1	rs12091564	0.037	rs10218795	0.034	1.75 × 10−7	1.75 × 10−7	CC (R)	0.92	1	1	HFE2	Yes
3	rs11924705	0.423	rs6789378	0.416	4.04 × 10−14	7.34 × 10−14	CA (P)	0.96	0.98	1	>1 Mb from any   gene	No
4	rs7697839	0.026	rs7673097	0.023	2.19 × 10−11	2.19 × 10−11	GG (R)	0.89	1	2	STK32B	No
9	rs1333048	0.477	rs1333049	0.494	7.08 × 10−14	2.55 × 10−13	GG (P)	0.92	0.99	18	115 kb from   CDKN2B/2A	Yes
10	rs2066314	0.016	rs2066315	0.034	8.6 × 10−2*	1.18 × 10−8	GT (R)	0.36	0.87	1	DIP2C	No
12	rs1165668	0.260	rs1165669	0.261	3.05 × 10−9	5.32 × 10−9	GC (R)	0.98	0.99	1	10 kb from   HSP90B1	Yes

Two and three degree of freedom (df) logistic model results for CAD. If multiple SNP pairs showed significant association with a P value <5 × 10⁻⁷, only the lowest P value pair is shown. The asterisk for the SNP pair on chromosome (Ch) 10 denotes a SNP pair only reaching genome-wide significance with 3 df model testing. Mean allele frequency (MAF) refers to the MAF of SNP 1 and SNP 2, respectively. The associated risk (R) or protective (P) haplotypes (Hap) are given. Correlation (R ²) and linkage disequilibrium (D′) values for the individual SNP pairs are listed. The “Pairs” column displays the number of SNP pairs in the area with a P value <5 × 10⁻⁷. Please refer to the text for specific information on the CAD linking literature. Italics indicate genes