Table 2.

Two-marker logistic model association test results for hypertension

Ch	SNP1	MAF1	SNP2	MAF2	2 df P value	3 df P value	Hap	R2	D′	Pairs	Gene	HTN Link?
2	rs10496288	0.104	rs10496289	0.098	2.08 × 10−9	7.32 × 10−9	GC (P)	0.96	1	1	H: > 1 Mb from any   gene	No
2	rs13420028	0.200	rs10188442	0.204	1.03 × 10−10	4.98 × 10−10	AA (P)	0.97	0.99	1	GPR39	No
5	rs7735940	0.240	rs12522034	0.250	5.47 × 10−13	3.04 × 10−12	AC (R)	0.95	0.99	1	>200 kb from   RANBP3L	No
5	rs6452524	0.442	rs6887846	0.448	1.69 × 10−7	7.12 × 10−7	GA (P)	0.98	0.99	1	XRCC4	No
6	rs3798440	0.157	rs9350602	0.151	3.38 × 10−10	7.43 × 10−10	AC (P)	0.96	1	2	MYO6	No
8	rs2469997	0.186	rs6469823	0.181	3.25 × 10−16	2.22 × 10−15	GC (R)	0.97	1	2	70 kb from NOV	No   (?)
8	rs7827545	0.321	rs1372662	0.333	1.65 × 10−44	4.11 × 10−44	CG (R)	0.95	1	2	ZFAT	Yes
12	rs7960483	0.331	rs10785581	0.338	1.43 × 10−7	6.27 × 10−7	TC (P)	0.97	0.99	1	~100 kb from   AN06	No
20	rs200752	0.115	rs200759	0.113	6.65 × 10−09	3.34 × 10−08	TA (R)	0.92	0.96	1	MACROD2	Yes

Two degree of freedom (df) logistic model results for HTN. If multiple SNP pairs showed significant association with a P value <5 × 10⁻⁷, only the lowest P value pair is shown. Mean allele frequency (MAF) refers to the MAF of SNP 1 and SNP 2, respectively. The associated risk (R) or protective (P) haplotypes (Hap) are given. Correlation (R ²) and linkage disequilibrium (D′) values for the individual SNP pairs are listed by their respective chromosome (Ch). The “Pairs” column displays the number of SNP pairs in the area with a P value <5 × 10⁻⁷. Please refer to the text for specific information on the HTN linking literature. Italics indicate genes. The (?) symbol is used for the SNP pair on chromosome (ch) 8, as NOV, which is 70 kb away from the associated SNP pair and has HTN linking literature