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. Author manuscript; available in PMC: 2014 Feb 13.
Published in final edited form as: J Am Chem Soc. 2013 Jan 31;135(6):2072–2075. doi: 10.1021/ja311367t

Figure 4.

Figure 4

(a) Schematic diagram of transcription amplification and AuNP-enhanced SPRI from an uncleaved bioaffinity sequence. (b) SPRI real-time binding data of AuNPs adsorbed onto detector (D), generator (G) and control (C) microarray elements from a 1 pM hTh sample. (c) Δ%R increase measured at 1000 seconds for AuNP adsorption onto detector microarray elements as a function of hTh concentration. The triangles indicate the average value from a set of microarray elements (hollow circles). A linear concentration dependence was observed with a detection limit of 100 fM.