. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Cancer Causes Control. 2012 Jun 2;23(8):1241–1251. doi: 10.1007/s10552-012-0002-2

Table 5.

Estimated hazard ratios for the effects of each MetS component examined on breast cancer risk among 8,956 participants from the Study of Osteoporotic Fractures^a

	Model 1^b			Model 2^c

	Hazard Ratio	95% Confidence Interval	P value	Hazard Ratio	95% Confidence Interval	P value
All breast cancers
Waist circumference ≥ 88 cm	1.18	0.97, 1,44	0.10	0.90	0.69, 1.18	0.44
Diabetes	1.29	0.90, 1.85	0.16	1.21	0.84, 1.76	0.30
Hypertension	1.05	0.86, 1.29	0.61	1.01	0.82, 1.24	0.93

Invasive only
Waist circumference ≥ 88 cm	1.18	0.95, 1.48	0.14	0.89	0.66, 1.20	0.43
Diabetes	1.27	0.85, 1.91	0.24	1.18	0.77, 1.80	0.44
Hypertension	0.96	0.77, 1.21	0.74	0.92	0.73, 1.15	0.46

ER Positive^d
Waist circumference ≥ 88 cm	1.30	1.03, 1.66	0.03	0.91	0.66, 1.26	0.57
Diabetes	1.47	0.98, 2.21	0.07	1.35	0.88, 2.06	0.17
Hypertension	1.06	0.83, 1.37	0.63	1.00	0.78, 1.29	0.99

PR Positive^d
Waist circumference ≥ 88 cm	1.51	1.16, 1.97	<0.01	0.93	0.65, 1.34	0.70
Diabetes	1.50	0.95, 2.37	0.08	1.34	0.83, 2.17	0.22
Hypertension	0.96	0.73, 1.27	0.79	0.89	0.67, 1.18	0.42

Hazard ratios are reported for waist circumference ≥88cm vs. waist circumference <88cm, diabetes vs. no diabetes, and hypertension vs. no hypertension

Model 1 adjusts for age, current hormone use, family history of breast cancer, and other MetS criteria (e.g. waist circumference adjusted for diabetes and hypertension)

Model 2 adjusts for BMI in addition to variables included in Model 1

Includes invasive cases only