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. Author manuscript; available in PMC: 2014 Feb 6.
Published in final edited form as: J Am Chem Soc. 2013 Jan 28;135(5):1735–1738. doi: 10.1021/ja4001823

Figure 1.

Figure 1

Biosynthesis of hypothemycin. Hpm8 assembles a hexaketide intermediate, which is then transferred to Hpm3. Hpm3 extends the hexaketide intermediate to DHZ. (Red intermediates were synthesized as 13C labeled SNAC thioesters).