Summary of results from recent randomized clinical trials for the treatment of amblyopia conducted by the Pediatric Eye Disease Investigator Group (PEDIG) (Holmes et al., 2006; Quinn et al., 2004; Repka and Holmes, 2012), the Monitored Occlusion Treatment of Amblyopia Study (MOTAS) Cooperative Group, (Stewart et al., 2002, 2005; Stewart et al., 2004a; Stewart et al., 2004b; Stewart et al., 2007a) and the Randomized Occlusion Treatment of Amblyopia (ROTAS) Cooperative Group.(Stewart et al., 2007b) Values represent mean improvement of visual acuity (logMAR) with 3–6 months of treatment. When more than one randomized clinical trial evaluated similar treatment plans, the range of means reported in the various studies is provided.