Tabel 1.

Echocardiographic Parameters by Time Since Randomization

Parameter	Baseline	Week 1	Week 5	p Value
LVFS (%)	36.0 ± 6.2 (189)	38.7 ± 5.0 (186)	37.8 ± 5.4 (185)	NS
LVFS z-score	−0.32 ± 2.22* (189)	0.70 ± 1.65† (186)	0.38 ± 1.93† (185)	<0.001
LV end-diastolic dimension z-score	0.54 ± 1.16† (189)	0.28 ± 1.20‡ (186)	0.31 ± 1.14† (185)	0.007
LV end-systolic dimension z-score	0.45 ± 1.54† (189)	−0.20 ± 1.34* (185)	0.04 ± 1.32 (185)	<0.001
Aortic root z-score	0.81 ± 0.85† (162)	0.94 ± 0.82† (169)	0.84 ± 0.87† (175)	0.129
Maximum coronary artery z-score	1.65 ± 1.48† (195)	1.73 ± 1.83† (190)	1.35 ± 1.81† (190)	<0.001

Values are mean ± SD (number of observations). Differs significantly from normal population mean,

^*p < 0.05;

^†p < 0.001;

^‡p < 0.01. The p value from longitudinal model assessing linear change over time.