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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Hypertension. 2013 Mar;61(3):673–680. doi: 10.1161/HYPERTENSIONAHA.111.00241

Figure 1.

Figure 1

Evidence for a functional intrarenal renin-angiotensin system in uninephrectomized conscious dogs. Panel A: Renal blood flow (RBF); Panel B: glomerular filtration rate (GFR); Panel C: Urinary Na+ excretion (UNaV) in response to intrarenal arterial administration of ACE inhibitor SQ-20881 (2 μg/kg/min) or Ang receptor blocker P-113 (saralasin; 2 μg/kg/min). Control vehicle infusion, white bars; experimental agent infusion, black bars. Sham data include vehicle infusion only. Data are expressed as mean ± 1 SE. Adapted from Kimbrough HM et al. Circ Res. 1977;40:174–178.