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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Hypertension. 2013 Mar;61(3):673–680. doi: 10.1161/HYPERTENSIONAHA.111.00241

Figure 3.

Figure 3

Ang II releases renal bradykinin (BK) by AT2R activation. Renal interstitial fluid BK levels in response to intravenous infusion of Ang II, Losartan, an AT1R antagonist; PD, PD-123319, an AT2R antagonist, and combinations in Sprague-Dawley rats. Control vehicle infusions, white bars; experimental agent infusions, black bars. Data are expressed as mean ± 1 SE. * P<0.0001 from control; + P<0.05, ++P<0.0001 from Ang II alone. Data from Siragy HM et al. Am J Physiol Reg Int Comp Physiol. 1996;271:R1090–R1095 and Siragy HM and Carey RM, Hypertension 1999;33:1237–1242.