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Evidence that intrarenal dopamine controls renal Na+ excretion by a paracrine mechanism acting at the level of the renal tubule. Urinary Na+ excretion (UNaV) in uninephrectomized conscious dogs infused intrarenally with D1-LIKE receptor antagonist SCH-23390. Data are expressed as mean ± 1 SE. * P<0.001, ** P<0.0001 from pre-control; † P<0.05, †† P<0.01 from time control. Adapted from Siragy HM et al. Am J Physiol Renal Physiol. 1988;257:F469–F477 with permission.
