Table 3.
Onset, duration, functionality and clinical imaging
| Case number | Gender/age at onset | Years since onset/WAB-AQ | Initial symptoms as reported by patient/informant |
Functionality in daily living activities in areas other than language | Global function (CDR/MMSE) | Diagnostics prior to entry into this study |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WF | SP | SY | CO | MI | NU | OR | MRI/CT | PET | |||||
| P1-G | M/53 | 5/90 | + | + | + | Unimpaired, out of work for unrelated reasons, active in complex hobby. | 1/24 | Negative | NA | ||||
| P2-G | M/61 | 1–2/93 | + | + | + | Unimpaired, but retired due to the aphasia. | 0/28 | Negative | Left hemisphere | ||||
| P3-G | M/50 | 1–2/93 | + | + | + | + | Unimpaired, working. | 0.5/27 | Left parietal | NA | |||
| P4-G | M/60 | 1–2/95 | + | + | Unimpaired, working. | 1/29 | Negative | NA | |||||
| P5-G | F/55 | 1–2/88 | + | + | Part-time work as health care professional. | 0.5/26 | Negative | Left temporoparietal | |||||
| P6-G | F/79 | 1–2/94 | + | + | + | Unimpaired, holds major board membership. | 0.5/30 | Negative | NA | ||||
| P7-G | F/71 | 4/89 | + | Unimpaired, civic, social activities maintained. | 0.5/30 | Negative | NA | ||||||
| P8-G | F/60 | 1–2/94 | + | + | + | Unimpaired, but retired due to the aphasia. | 0.5/26 | Negative | NA | ||||
| P9-G | M/66 | 1–2/94 | + | + | Unimpaired, working. | 1.5/26 | Non-focal atrophy | NA | |||||
| P10-Sp | M/66 | 3/97 | + | + | + | Unimpaired, but retired due to the aphasia. | 2.5/30 | Negative | Negative | ||||
| P11-S | F/51 | 3/95 | + | + | Unimpaired, but less invested in customary activities. | 2.5/29 | Left hemisphere | NA | |||||
| P12-S | M/59 | 4/88 | + | + | Stopped work, mild disinhibition, drives, independent in daily living. | 4/27 | CT-left anterotemporal | NA | |||||
| P13-S | F/60 | 1–2/85 | + | + | Continues part-time work, pursues complex hobby. | 1.5/24 | Left temporal | NA | |||||
| P14-S | M/64 | 1–2/87 | + | Stopped work for unrelated reasons, travels widely, has complex hobby. | 1/28 | Left anterotemporal | NA | ||||||
| P15-L | M/66 | 3/92 | + | Unimpaired, retired for unrelated reasons, performs complex chores. | 0/30 | Negative | Minimally abnormal | ||||||
| P16-L | M/58 | 5/97 | + | Unimpaired, but retired due to the aphasia, volunteers in high-level activity. | 0.5/27 | Negative | NA | ||||||
| P17-L | M/56 | 1–2/87 | + | + | Had to retire, performs complex chores at home, less confident in driving. | 1/23 | Non-focal atrophy | Left temporoparietal | |||||
| P18-L | F/72 | 1–2/97 | + | Unimpaired, successful in competitive hobby. | 0/28 | Negative | Left hemisphere | ||||||
| P19-L | F/74 | 4/89 | + | + | + | Unimpaired. | 0/24 | Non-focal atrophy | NA | ||||
| P20-L | F/53 | 4/95 | + | Unimpaired, working | 1/30 | Negative | Left hemisphere | ||||||
| P21-M | F/55 | 8/88 | + | + | + | Quit job due to the aphasia, otherwise independent. | 2/26 | CT-negative | NA | ||||
| P22-M | F/76 | 1–2/88 | + | + | Unimpaired. | 0.5/28 | Negative | NA | |||||
| P23 | M/63 | 1–2/90 | + | + | + | Unimpaired, working. | 1/29 | Left hemisphere | Left hemisphere | ||||
| P24 | M/60 | 3/96 | + | Unimpaired, working. | 0/29 | Negative | Negative | ||||||
| P25 | F/75 | 3/92 | + | Unimpaired. | 2/29 | Negative | NA | ||||||
CDR = Clinical Dementia Rating Scale, Sum of Boxes (range 0–18, 18 is most impaired); CO = word comprehension impairment; F = female, M = male; MI = misuse of words (as in semantic paraphasias); MMSE = Mini-Mental State Examination (range 0–30, 30 is most preserved); NA = data not available; NU = impaired handling of numbers (arithmetic); OR = errors in orthography (spelling); SP = speech impairment; SY = abnormal syntax (word order); WAB-AQ = Aphasia quotient of the Western Aphasia Battery; WF = word-finding impairment.