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. 2011 Dec 28;29(4):630–636. doi: 10.3892/ijmm.2011.870

Figure 4.

Figure 4

Effects of ERK and Akt inhibitors on CHPG-induced neuroprotection. CHPG was added into culture medium (1 mM) or injected into right lateral ventricle (250 nM) in the presence of the ERK inhibitor PD98059 and/or LY294002, a selective inhibitor of Akt. Then the LDH release (A), apoptosis in cultured neurons (B), TUNEL-positive cells (C) and lesion volume (D) were assayed. The data are presented as means ± SD, n=6 independent experiments (A and B), n=5 independent experiments (C and D). *P<0.05 vs. TBI group; #P<0.05 vs. CHPG+TBI group.