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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: Sci Transl Med. 2013 Jan 23;5(169):169ra10. doi: 10.1126/scitranslmed.3005211

Figure 2. DNA methylation alterations are heterogeneous across individuals, but closely maintained in the metastases within each individual.

Figure 2

Between-sample correlation for (A) total DNA methylation (TM), and (B) allele-specific DNA methylation (ASM). Axis labels indicate tissue type (tumor vs. normal) and subject identifier. The light colored block diagonal structure shows high inter-individual correlation for normal tissues (bottom left) and high intra-individual correlation and inter-individual heterogeneity for metastases. (C) DNA methylation hierarchical clustering showing high within-subject similarity and between-subject heterogeneity of metastases. These analyses were done using the 500 probes showing greatest variability across all samples.