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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: Sci Transl Med. 2013 Jan 23;5(169):169ra10. doi: 10.1126/scitranslmed.3005211

Figure 4. Gene expression patterns show high within-subject maintenance and correlation with DNA hypermethylation.

Figure 4

(A) Gene expression hierarchical clustering showing high within-subject similarity and between-subject heterogeneity of metastases. These analyses were done using the 500 genes showing greatest variability in gene expression across all 21 benign and 18 metastasis samples with gene expression microarray data. (B) DNA promoter hypermethylation shows significant correlation with downregulation of gene expression (average fold decrease = 1.33, p=5.87 × 10−38) and is more strongly correlated with gene expression than promoter hypomethylation (p=9.2 × 10−8). (C) Within-subject maintenance (R2) of gene expression patterns for genes with significant correlation between DNA methylation and gene expression was stronger than for genes having no evidence for methylation-expression correlation.