Table 1.
Summary of Stage 3 replication genotyping results.
| Gene | Single-marker analysis (57 SNVs) | Gene-based analysis (35 SNVs) | ||||||
|---|---|---|---|---|---|---|---|---|
| # SNVs | EUR (minimum p-value) | AFR (minimum p-value) | # uncommon variants | EUR (# of case/control alternative allele) | EUR p-values (CALPHA/VT) | AFR (# of case/control alternative allele) | AFR p-values (CALPHA/VT) | |
| COMT | 4 | 0.037 | 0.128 | 3 | 8/1 | 0.02/0.003 | 0/3 | 0.29/0.71 |
| DAOA | 5 | 0.039 | 0.121 | 0 | - | - | - | - |
| DISC1 | 22 | 0.099 | 0.081 | 20 | 32/40 | 0.67/0.33 | 39/32 | 0.27/0.08 |
| DRD3 | 3 | 0.375 | 0.264 | 0 | - | - | - | - |
| DTNBP1 | 5 | 0.390 | 0.106 | 5 | 18/19 | 0.32/0.72 | 7/4 | 0.34/0.16 |
| HTR2A | 3 | 0.037 | 0.380 | 1 | 3/13 | 0.03/0.7 | 0/1 | 0.71/0.71 |
| NRG1 | 8 | 0.119 | 0.017 | 1 | 4/1 | 0.14/0.1 | 159/185 | 0.34/0.15 |
| SLC6A3 | 4 | 0.339 | 0.326 | 2 | 4/4 | 0.6/0.8 | 0/1 | 0.76/0.67 |
| SLC6A4 | 3 | 0.418 | 0.310 | 3 | 10/9 | 0.45/0.25 | 1/1 | 0.4/0.36 |
Single-marker and aggregate analyses of EUR and AFR samples. Logistic regression was performed on 57 SNVs. Gene-based analysis was performed on 35 exonic SNVs.