Table 3.
Antifungal susceptibility profile of oral Candida isolates from AIDS patients, northwest Ethiopia, 2008/09
| Species/Antifungal agent |
MIC (μ/ml) |
SDD | R: n (%) | ||
|---|---|---|---|---|---|
| MIC Range | MIC50 | MIC90 | |||
| All isolates (90) |
|
|
|
|
|
| Fluconazole |
0.125–64 |
0.25 |
2 |
3 (3.3) |
11 (12.2) |
| Ketoconazole |
0.016–16 |
2 |
4 |
- |
7 (7.7) |
| Itraconazole |
0.016–16 |
0.016 |
0.063 |
3 (3.3) |
4 (4.7) |
| Amphotericin B |
0.125– 8 |
0.125 |
0.125 |
- |
3 (3.5) |
| 5-Fuorocytosine |
0.125–16 |
0.125 |
0.125 |
- |
2 (2.3) |
| Micafungin |
0.015–8 |
0.06 |
1.2 |
- |
2 (2.3) |
|
C. albicans (25) |
|
|
|
|
|
| Fluconazole |
0.125–64 |
0.25 |
2 |
1 (4) |
4 (16) |
| Ketoconazole |
0.016–16 |
- |
3 (12) |
|
|
| Itraconazole |
0.016–16 |
0.016 |
0.063 |
3 (12) |
2 (8) |
| Amphotericin B |
0.125–8 |
0.5 |
0.5 |
- |
1 (4) |
| 5-Fuorocytosine |
0.125–16 |
- |
- |
- |
1 (4) |
| Micafungin |
0.015–8 |
- |
- |
- |
1 (4) |
|
C. glabrata (25) |
|
|
|
|
|
| Fluconazole |
0.125–64 |
0.25 |
2 |
1 (6) |
3 (8) |
| Ketoconazole |
0.016–16 |
- |
- |
- |
1 (4) |
| Itraconazole |
0.016–16 |
0.016 |
0.063 |
2 (12) |
1 (4) |
| Amphotericin B |
0.125–8 |
0.5 |
- |
- |
- |
| 5-Fuorocytosine |
0.125–16 |
- |
- |
- |
1 (4) |
| Micafungin |
0.015–8 |
- |
- |
- |
- |
|
C. tropicalis (25) |
|
|
|
|
|
| Fluconazole |
0.125–64 |
0.25 |
2 |
- |
2 (8) |
| Ketoconazole |
0.016–16 |
- |
1 (4) |
|
|
| Itraconazole |
0.016–16 |
0.016 |
0.063 |
2 (12) |
1 (4) |
| Amphotericin B |
0.125–8 |
0.5 |
0.5 |
- |
- |
| 5-Fuorocytosine |
0.125–16 |
- |
- |
- |
1 (4) |
| Micafungin |
0.015–8 |
- |
- |
- |
- |
|
C. krusei (10) |
|
|
|
|
|
| Fluconazole |
0.125–64 |
0.25 |
2 |
1 (10) |
1 (10) |
| Ketoconazole |
0.016–16 |
- |
- |
- |
1 (10) |
| Itraconazole |
0.016–16 |
0.016 |
0.063 |
1 (10) |
- |
| Amphotericin B |
0.125–8 |
0.5 |
- |
- |
- |
| 5-Fuorocytosine |
0.125–16 |
- |
- |
- |
- |
| Micafungin |
0.015–8 |
- |
- |
- |
- |
| Other Candida species* (5) |
|
|
|
|
|
| Fluconazole |
0.125–64 |
0.25 |
2 |
- |
1 (20) |
| Ketoconazole |
0.016–16 |
- |
- |
- |
1 (20) |
| Itraconazole |
0.016–16 |
0.016 |
0.063 |
1 (10) |
- |
| Amphotericin B |
0.125–8 |
- |
- |
- |
- |
| 5-Fuorocytosine |
0.125–16 |
- |
- |
- |
- |
| Micafungin | 0.015–8 | - | - | - | - |
*: Unidentified Candida species.