Table 1.
Demographic and clinical characteristics of HCs, all MS patients, and MS subtypes
| |
Disease group (n) |
|||||||
|---|---|---|---|---|---|---|---|---|
| HCs (38) | All MS (146) | P value | CIS (16) | PPMS (19) | RRMS (53) | SPMS (58) | P value | |
| Age (y) |
37±10 |
40±9 |
0.112 |
32±7 |
48±11 |
37±9 |
43±7 |
0.001a |
| mean (±SD) | ||||||||
| M/F |
18/20 |
49/97 |
0.115 |
6/10 |
6/13 |
13/40 |
17/41 |
0.001b |
| EDSS |
|
4 |
|
2.3 |
5.5 |
3.0 |
5.0 |
0.001a |
| median (range) |
|
(1.5-7.0) |
|
(1.5-3.5) |
(3.5-7.0) |
(2.0-5.0) |
(2.5-7.0) |
|
| MSSS |
|
5.3 |
|
6.3 |
5.3 |
5.4 |
4.9 |
0.122 |
| median (range) |
|
(1.2-9.5) |
|
(2.1-8.6) |
(3.7-9.1) |
(1.5-8.6) |
(1.6-9.4) |
|
| Disease duration (y) |
|
11 |
|
1 |
13 |
7 |
16 |
0.001a |
| median (range) |
|
(0–35) |
|
(0–11) |
(4–24) |
(1–29) |
(3–35) |
|
| Onset age (y) |
|
28.0 |
|
29.3 |
35.0 |
27.6 |
27.0 |
0.036c |
| median (range) | (13.0-57.0) | (18.5-41.0) | (18–57) | (15–46) | (13–44) | |||
aAge, EDSS, and disease duration were significantly higher in PPMS and SPMS patients than in CIS and RRMS patients.
bMale sex was significantly prevalent in PP patients.
cOnset age was significantly higher in PPMS patients than in RR and SP patients.
Abbreviations: CIS: clinically isolated syndrome; HCs: healthy controls; MS: multiple sclerosis; PPMS: primary progressive multiple sclerosis; RRMS: relapsing-remittent multiple sclerosis; SPMS: secondary progressive multiple sclerosis.