Table 2.
Sensitivity, specificity, and odds ratios of single colour Doppler sonography criteria in MS patients and HCs
| Sensitivity, % (95% CI) | Specificity, % (95% CI) | Odds ratio, (95% CI) | |
|---|---|---|---|
| Reflux of the IJV and/or VV (Cr 1) |
63,0 |
78,9 |
6,4 |
| (55,0-70,5) |
(64,2-89,5) |
(2,7-14,9) |
|
| Intracranial reflux (Cr 2) |
28,1 |
84,2 |
2,1 |
| (21,3-35,8) |
(70,3-93,1) |
(0,8-5,4) |
|
| IJV stenosis B-mode anomalies (Cr 3) |
80,8 |
52,6 |
4,7 |
| (73,9-86,6) |
(37,1-67,8) |
(2,2-10,0) |
|
| No flow in the IJV and/or VV (Cr 4) |
26,7 |
97,4 |
13,5 |
| (20,0-34,3) |
(88,4-99,6) |
(1,8-101,6) |
|
| Negative CSA (Cr 5) |
6,2 |
97,4 |
2,4 |
| (3,1-10,9) |
(88,4-99,6) |
(0,3-19,8) |
|
| CCSVI |
76,0 |
84,2 |
16,9 |
| (68,6-82,4) | (70,3-93,1) | (6,5-43,8) |
An odds ratio greater than 1.0 indicates an increased likelihood of a diagnosis of CCSVI in MS patients versus controls.
Abbreviations: MS: multiple sclerosis; HCs: healthy controls; CCSVI: chronic cerebrospinal venous insufficiency; Cr: criterion; IJV: internal jugular vein; VV: vertebral vein; CSA: cross sectional area; CI: confidence interval.