. 2012 Sep 11;13:225. doi: 10.1186/1471-2105-13-225

Table 2.

CMF-significant essential sites in human GCK protein, which are nearby either nsSNPs or strictly conserved sites

**CMF-significant essential sites**	Nearby nsSNPs or strictly conserved sites	Reference
M34	36^s	[34]
T65	66^c
E67	66^c, 68^c	-
T82	81^c	-
N83	81^c, 108^s, 110^s	[34]
H105	106^s	[29]
C129	131^s, 132^s	[29,34]
F133	131^s, 132^s	[29,34]
F148	147^c, 150^c,s	[34]
F152	150^c,s, 151^c	[34]
H156	162^s	[29]
N180	162^s, 182^s	[29,34]
F260	257^s, 258^c, 259^s, 261^s	[34]
D262	259^s, 261^s, 264^s	[34,42]
L266	261^s, 264^s, 265^s	[29,34,42]
D267	264^s, 265^s	[29,42]
L271	274^c	-
S281	278^c, 279^s	[34]
Q286	259^s	[34]
E331	299^c,s	[34]
T332	295^c, 299^c,s	[34]
R333	336^s	[34]
Q337	336^s	[34]
E339	336^s	[34]
N391	392^s	[29,34]
S411	227^c,s, 410^c, 414^s	[34]
S418	416^s	[30]
F419	416^s	[30]
E442	444^c	-
E443	444^c, 445^c	-

^s: non-synonymous snp site,^c: strictly conserved site.