Table 3.
Sputum mediator concentrations for subjects stratified by the median RB1 total area and luminal area
| Total | Low total area | High total area | p value | Low luminal area | High luminal area | p value | |
|---|---|---|---|---|---|---|---|
| Factor VII* |
2.15 [1.89-2.43] |
2.03 [1.69-2.44] |
2.27 [1.89-2.72] |
0.40 |
2.01 [1.68-2.41] |
2.30 [1.91-2.77] |
0.25 |
| Fibrinogen* |
240 [172–335] |
260 [161–421] |
223 [137–364] |
0.48 |
291 [184–461] |
200 [121–330] |
0.16 |
| Ferritin* |
2.21 [1.54-3.17] |
2.56 [1.62-4.06] |
1.94 [1.10-3.42] |
0.38 |
2.21 [1.35-3.61] |
2.21 [1.27-3.85] |
0.9 |
| IL-1 α |
27 [19-37] |
35 [23–54] |
20 [12-33] |
0.13 |
38 [25–58] |
19 [12-30] |
0.041 |
| IL-1 β |
47 [31–71] |
44 [26–76] |
49 [25–96] |
0.40 |
45.4 [26.72-77.14] |
48.8 [25–95.4] |
0.40 |
| IL-1RA |
6951 [5168–9350] |
8147 [5120–12964] |
5962 [4033–8815] |
0.59 |
9108 [5752–14421] |
5353 [3662–7824] |
0.19 |
| IL-6 |
41 [30–56] |
32 [20–53] |
52 [35–76] |
0.14 |
33.3 [20.5-54.1] |
51.8 [35.3-76.1] |
0.16 |
| IL-8 |
3608 [2462–5287] |
2846 [1599–5064] |
4537 [2686–7665] |
0.37 |
3062 [1790–5237] |
4227 [2393–7469] |
0.43 |
| IL-15 |
440 [370–520] |
410 [320–540] |
460 [360–600] |
0.60 |
410 [320–540] |
460 [360–600] |
0.60 |
| IL-18 |
40.2 [32.2-50.2] |
37.2 [27–51.3] |
43.3 [31.2-6] |
0.31 |
39.2 [27.7-55.5] |
41.2 [30.5-55.6] |
0.53 |
| TNF-α |
6.46 [4.58-9.12] |
4.66 [3.45-7.30] |
9.35 [3.91-17.8] |
0.09 |
4.71 [3.48-6.36] |
9.25 [4.84-17.6] |
0.06 |
| TNFR2 |
330 [230–490] |
280 [160–510] |
390 [220–670] |
0.46 |
290 [160–500] |
390 [220–680] |
0.39 |
| CCL2 |
100 [75–134] |
96 [62–150] |
105 [71–156] |
0.35 |
100 [65–153] |
101 [67–153] |
0.98 |
| CCL4 |
462 [313–682] |
380 [241–600] |
554 [291–1052] |
0.42 |
349 [220–555] |
611 [322–1158] |
0.036 |
| CCL11 |
59.8 [48.4-73.9] |
48.3 [39.2-59.6] |
76.3 [52.4-111] |
0.026 |
49.1 [39.7-60.7] |
74.9 [51.3-109] |
0.043 |
| MMP-3* |
0.25 [0.19-0.33] |
0.27 [0.18-0.40] |
0.23 [0.16-0.33] |
0.51 |
0.26 [0.18-0.39] |
0.24 [0.16-0.34] |
0.56 |
| MMP-9* |
38.1 [26.7-54.3] |
48.8 [29.1-81.8] |
30.3 [18.3-50] |
0.11 |
50.8 [31.6-81.7] |
29.1 [17.1-49.5] |
0.09 |
| TIMP-1* |
108 [78.6-14] |
93 [56–155] |
124 [82–188] |
0.33 |
98 [60–159] |
118 [75–185] |
0.40 |
| ICAM-1 |
2900 [2170–3870] |
2490 [1650–3740] |
3370 [2200–5150] |
0.32 |
2400 [1620–3550] |
3530 [2280–5460] |
0.19 |
| VCAM-1 |
1130 [850–1490] |
1240 [830–1860] |
1003 [690–1560] |
0.80 |
1200 [820–1760] |
1060 [690–1630] |
0.78 |
| VEGF | 837 [678–1033] | 793 [592–1061] | 882 [640–1214] | 0.51 | 823 [617–1098] | 851 [616–1175] | 0.83 |
All units are pg/ml except *denoting ng/ml, data represented as Geometric mean [95% CI].