Table 4.
Clinical features of subjects stratified by the median neutrophil count (%) and RB1 total area
| Low neutrophil, Low total area | High neutrophil, Low total area | Low neutrophil, High total area | High neutrophil, High total area | p value | |
|---|---|---|---|---|---|
| N |
14 |
15 |
13 |
17 |
|
| Male, n |
5 |
9 |
3 |
8 |
0.24 |
| Current age |
52 (3) |
54 (3) |
44 (4) |
47 (3) |
0.15 |
| Age of onset |
36 (5) |
31 (5) |
24 (5) |
20 (4) |
0.08 |
| BMI, kg/m2 |
32.7 (1.6) |
32 (2) |
24.4 (1.4) |
29.7 (0.8) |
0.002 |
| Habitual and ex smokers with >10 pack year history |
4 |
5 |
2 |
2 |
0.95 |
| Pack years history |
6.5 (3) |
14.5 (9) |
7 (4) |
5 (3) |
0.59 |
| Severe Exacerbations |
1.5 (0.5) |
2.5 (0.4) |
2.5 (0.6) |
4 (0.6) |
0.01 |
| IgE |
208 |
221 |
270 |
119 |
0.28 |
| ACQ6 |
2.2 (0.25) |
2.2 (0.26) |
1.9 (0.31) |
2.3 (0.27) |
0.68 |
| Subjects taking oral corticosteroids, n |
7 |
8 |
4 |
6 |
0.87 |
| Daily Predinsolone dose, mg |
6 (1.9) |
5.5 (1.6) |
3 (1.5) |
2 (0.7) |
0.14 |
| Pre Bronchodilator FEV1 |
2.21 (0.3) |
2.29 (0.2) |
2.24 (0.2) |
2.31 (0.25) |
0.99 |
| Post Bronchodilator FEV1 |
2.36 (0.3) |
2.48 (0.2) |
2.41 (0.2) |
2.42 (0.25) |
0.98 |
| Bronchodilatorreversibility, mls |
0.15 (0.03) |
0.46 (0.2) |
0.17 (0.06) |
0.11 (0.04) |
0.28 |
| Pre Bronchodilator FVC |
3.12 (0.3) |
3.31 (0.2) |
3.33 (0.2) |
3.26 (0.32) |
0.96 |
| Post Bronchodilator FVC |
3.24 (0.3) |
3.49 (0.2) |
3.39 (0.2) |
3.28 (0.32) |
0.92 |
| Pre Bronchodilator FEV1 % of predicted |
74.4 (8.2) |
77.6 (5.6) |
76.7 (4.9) |
74.1 |
0.93 |
| Post Bronchodilator FEV1 % of predicted |
79.4 (7.8) |
82.1 (6.2) |
83.4 (4.3) |
83.8 |
0.94 |
| Bronchodilator Reversibility % FEV1 |
5.03 (1.1) |
5.8 (1.3) |
6.7 (1.9) |
5.5 (1.6) |
0.94 |
| Pre Bronchodilator FEV1/FVC ratio |
69.8 (4.1) |
69.8 (3.5) |
68 (3.3) |
70.3 (4.1) |
0.97 |
| Post Bronchodilator BD FEV1/FVC ratio |
72.1 (4) |
70.7 (3.1) |
72.9 |
73.2 (4) |
0.96 |
| Total Cells |
0.53 [0.2-1.43] |
0.7 [0.41-1.4] |
0.31 [0.15-0.63] |
0.82 [0.4-1.4] |
0.79 |
| Neutrophils % |
35 [19.6-62.5] |
86 [80.5-91.9] |
39.5 [29.5-52.5] |
83.8 [78.4-88.6] |
<0.001 |
| Eosinophils % |
2.8 [1.1-7] |
2.2 [0.9-9.3] |
3.7 [1.4-10.8] |
1.2 [0.2-2.7] |
0.16 |
| Bronchiectasis present n (%) |
2 (14) |
5 (33) |
5 (38) |
11 (65) |
0.03 |
| Bronchial Wall Thickening present |
10 (70) |
11 (73) |
8 (62) |
10 (63) |
0.87 |
| Lumen area/Body Surface Area (mm2/m2) |
3.6 (0.26) |
3.3 (0.35) |
7.1 (0.66) |
7.2 (0.58) |
<0.001 |
| Total area/Body Surface Area (mm2/m2) | 13.3 (0.54) | 12.1 (0.67) | 21.8 (1.64) | 23.6 (1.27) | <0.001 |