Table 6.
Clinical features of subjects stratified by the median neutrophil count (%) and RB1 luminal area
| Low neutrophil, Low luminal area | High neutrophil, Low luminal area | Low neutrophil, High luminal area | High neutrophil, High luminal area | p value | |
|---|---|---|---|---|---|
| N |
13 |
16 |
14 |
16 |
|
| Male |
4 |
10 |
4 |
7 |
0.22 |
| Current age |
52 (3) |
54 (3) |
44 (3) |
46 (3) |
0.14 |
| Age of onset |
35 (4) |
31 (4) |
25 (4) |
20 (4) |
0.16 |
| BMI, kg/m2 |
32.8 (1.7) |
32.4 (1.8) |
24.9 (1.4) |
29.1 (0.8) |
<0.001 |
| Habitual smokers and ex smokers with >10 py |
4 |
6 |
2 |
1 |
0.86 |
| Pack years history |
7 (3) |
15 (8) |
6.5 (4) |
4 (3) |
0.48 |
| Severe Exacerbations |
1.5 |
2 |
2 |
4 |
0.05 |
| IgE |
266 |
212 |
174 |
141 |
0.38 |
| ACQ6 |
2.11 (0.24) |
2.29 (0.24) |
1.98 (0.30) |
2.29 (0.28) |
0.82 |
| Subjects taking oral corticosteroids |
7 |
7 |
4 |
7 |
0.84 |
| Daily predinosolone dose, mg |
6.9 (2) |
3.9 (1.2) |
3.0 (1.4) |
3.4 (1.3) |
0.30 |
| Pre Bronchodilator FEV1 |
2.15 (0.32) |
2.21 (0.2) |
2.29 (0.19) |
2.39 (0.25) |
0.90 |
| Pre Bronchodilator FEV1 % predicted |
2.29 (0.31) |
2.37 (0.22) |
2.47 (0.2) |
2.53 (0.24) |
0.90 |
| Bronchodilator reversibility, ml |
0.14 (0.02) |
0.42 (0.25) |
0.18 (0.05) |
0.14 (0.04) |
0.44 |
| Pre Bronchodilator FVC |
3.07 (0.37) |
3.18 (0.27) |
3.37 (0.2) |
3.40 (0.31) |
0.84 |
| Pre Bronchodilator FVC |
3.17 (0.37) |
3.36 (0.28) |
3.44 (0.2) |
3.41 (0.31) |
0.92 |
| Pre Bronchodilator FEV1 % of predicted |
74.8 (8.9) |
73.9 (5.7) |
76.1 (4.5) |
75.9 (5.3) |
0.99 |
| Post Bronchodilator FEV1 % of predicted |
79.7 (8.4) |
77.4 (6.2) |
82.8 (4) |
83.4 (4.9) |
0.87 |
| BD Bronchodilator Reversibility % FEV1 |
4.8 (1.1) |
4.7 (1.1) |
6.7 (1.8) |
7.4 (2.8) |
0.68 |
| Pre Bronchodilator FEV1/FVC ratio |
69.2 (4.4) |
70 (3.3) |
68.7 (3.2) |
70.1 (4.3) |
0.99 |
| Post Bronchodilator FEV1/FVC ratio |
71.4 (4.3) |
70.1 (2.8) |
72.9 (2.8) |
74 (4.2) |
0.87 |
| Total Cells |
0.45 [0.16-1.2] |
0.80 [0.45-1.4] |
0.37 [0.17-0.80] |
0.8 [0.4-1.5] |
0.74 |
| Neutrophils % |
33.6 [18–62.7] |
85.2 [79–91.1] |
40.7 [30.9-53.6] |
83.9 [78.9-89.6] |
<0.001 |
| Eosinophils % |
2.7 [1–7.4] |
1.9 [0.7-4.5] |
3.7 [1.5-9.3] |
1.4 [0.6-3.2] |
0.32 |
| Bronchiectasis present |
2 (15) |
7 (44) |
5 (36) |
9 (60) |
0.15 |
| Bronchial Wall Thickening present |
10 (77) |
12 (75) |
8 (57) |
9 (60) |
0.59 |
| Lumen area/Body Surface Area (mm2/m2) |
3.4 (0.2) |
3.1 (0.2) |
7.0 (0.6) |
7.6 (0.4) |
<0.001 |
| Total area/Body Surface Area (mm2/m2) | 13.1 (0.5) | 13.31 (1.1) | 21.3 (1.5) | 23.1 (1.4) | <0.001 |