Table 7.
Sputum mediator concentrations for subjects stratified by the median neutrophil count (%) and RB1 luminal area
| Low neutrophil, Low luminal area | High neutrophil, Low luminal area | Low neutrophil, High luminal area | High neutrophil, High luminal area | p value | |
|---|---|---|---|---|---|
| Factor VII* |
2.23 [1.58-3.16] |
1.85 [1.51-2.26] |
2.03 [1.53-2.69] |
2.54 [1.95-3.31] |
0.36 |
| Fibrinogen* |
270 [160–460] |
306 [141–662] |
101 [65–157] |
363 [166–793] |
0.037 |
| Ferritin |
2280 [990–5220] |
2150 [1100–4200] |
1780 [1050–2990] |
2750 [950–7900] |
0.6 |
| IL-1 α |
43 [20–90] |
34 [19–61] |
13 [7–23] |
26 [12–54] |
0.14 |
| IL-1 β |
34.3 [16.2-72.6] |
57 [25.1-127] |
17 [9.81-29.4] |
121 [45.8-323] |
0.005 |
| IL-1RA |
9021 [3972–20484] |
9180 [5058–16662] |
4183 [2386–7332] |
6642 [3826–11532] |
0.054 |
| IL-6 |
40.5 [18.5-88.7] |
28.5 [14.2-57.2] |
41.2 [24.6-68.9] |
65.3 [35.3-120] |
0.20 |
| IL-8 |
3567 [1739–7316] |
2705 [1155–6335] |
3730 [2114–6581] |
4716 [1710–13009] |
0.49 |
| IL-15 |
400 [250–640] |
420 [290–610] |
409 [269–623] |
520 [360–740] |
0.54 |
| IL-18 |
37.3 [22.5-61.9] |
41.1 [23.9-70.6] |
33.4 [22.5-49.8] |
49.2 [30.8-78.7] |
0.19 |
| TNF-α |
4.62 [3.32-6.43] |
4.81 [2.55-9.05] |
5.53 [4.2-7.28] |
11.1 [4.58-27.1] |
0.19 |
| TNFR2 |
350 [130–920] |
250 [120–510] |
250 [140–440] |
550 [210–1410] |
0.59 |
| CCL2 |
158 [91–275] |
69.1 [37.4-127] |
104 [56.3-194] |
98.7 [52.7-184] |
0.38 |
| CCL4 |
357 [205–621] |
343 [159–742] |
861 [330–2245] |
464 [181–1189] |
0.10 |
| CCL11 |
56.7 [38.8-83.1] |
43 [33.8-54.6] |
122 [65.9-226] |
53.4 [34.2-83.6] |
0.013 |
| MMP-3* |
0.30 [0.14-0.62] |
0.24 [0.15-0.38] |
0.20 [0.12-0.34] |
0.27 [0.16-0.47] |
0.49 |
| MMP-9* |
37 [13–106] |
63.2 [40.1-99.5] |
13.9 [7.73-25] |
58.2 [27.3-124] |
0.0015 |
| TIMP-1* |
163 [110–241] |
65 [29–145] |
132 [73.5-239] |
107 [51.7-221] |
0.14 |
| ICAM-1 |
3960 [2100–7493] |
1600 [1030–2490] |
4890 [2400–9970] |
2660 [1500–4720] |
0.017 |
| VCAM-1 |
1270 [617–2620] |
1140 [734–1790] |
1140 [510–2560] |
990 [610–1580] |
0.54 |
| VEGF | 1192 [871–1632] | 609 [398–932] | 857 [537–136] | 845[512–1393] | 0.14 |
All units are pg/ml except *denoting ng/ml, data represented as Geometric mean [95% CI].