Figure 2.

Distinct transcription factor sets orchestrate different regulatory subprograms during germination. T-profiler prediction of (A) TFs and (B) consensus motifs involved in the germination of yeast spores on YPD. The absolute T-values indicate the probability of the transcription factor/motif activity and the sign indicates if the expression of the target genes is increased (red) or decreased (blue). The response appears to have three major phases; an early transient peak (Hsf1, Nrg1, Phd1, etc.), a sustained adaptation (Fhl1, Hap1, Msn2, Gcr1, etc.) and, eventually, initiation of the mating response (Ste12, Dig1). (C) The TF activity predictions in (B) were based on the following consensus motifs for the respective TFs. (D) The TFs identified both in the global analysis in (A) and for the eight gene expression subprograms identified in Figure 1B .