Table 5.
Regression analysis of variables affecting change in CAARS:O-SV score (main analysis set)
| Estimate | p-value | Difference in least squares means | p-value | |
|---|---|---|---|---|
| Baseline |
–0.4203 |
0.0007 |
– |
– |
| Prior adherence |
–0.0145 |
0.7530 |
– |
– |
| Treatment group: |
||||
| 54 mg |
2.6840 |
0.7436 |
–2.7528 |
0.0145 |
| 72 mg |
12.2774 |
0.1441 |
–4.5799 |
< 0.0001 |
| Baseline × Treatment group: |
||||
| 54 mg |
0.1473 |
0.3922 |
– |
– |
| 72 mg |
–0.2533 |
0.1448 |
– |
– |
| Time point (versus Week 13) |
||||
| Week 1 |
3.9770 |
0.0003 |
7.1825 |
0.0001 |
| Week 3 |
1.8149 |
0.0767 |
3.3609 |
< 0.0001 |
| Week 5 |
1.5768 |
0.0923 |
2.8016 |
< 0.0001 |
| Week 7 |
–0.0884 |
0.9186 |
0.8591 |
0.1023 |
| Week 9 |
0.3289 |
0.6653 |
0.5197 |
0.2625 |
| Time point × Treatment group |
||||
| Week 1 × 54 mg |
4.6804 |
0.0037 |
0.3118 |
0.8088 |
| Week 1 × 72 mg |
4.8763 |
0.0022 |
–1.6352 |
0.1917 |
| Week 3 × 54 mg |
2.1269 |
0.1603 |
–2.2417 |
0.0908 |
| Week 3 × 72 mg |
2.5112 |
0.0914 |
–4.0003 |
0.0020 |
| Week 5 × 54 mg |
1.8791 |
0.1753 |
–2.4895 |
0.0667 |
| Week 5 × 72 mg |
1.7954 |
0.1878 |
–4.7161 |
0.0004 |
| Week 7 × 54 mg |
0.7517 |
0.5571 |
–3.6169 |
0.0101 |
| Week 7 × 72 mg |
2.0907 |
0.0980 |
–4.4208 |
0.0013 |
| Week 9 × 54 mg |
0.2565 |
0.8192 |
–4.1121 |
0.0045 |
| Week 9 × 72 mg |
0.3160 |
0.7777 |
–6.1955 |
< 0.0001 |
| Treatment group × adherence |
||||
| 54 mg |
–0.1276 |
0.0197 |
– |
– |
| 72 mg |
–0.0976 |
0.0721 |
– |
– |
| Female sex |
–1.5429 |
0.0949 |
– |
– |
| No family history of ADHD |
2.4018 |
0.0104 |
– |
– |
| Time since ADHD diagnosis | 0.1403 | 0.0072 | – | – |