Table 1.
Core phenotyping in DIACORE
| Phenotype category | Item | Instrument for obtaining phenotype |
|---|---|---|
| General |
Current Medication |
Q |
| Ethnicity |
Q* |
|
| Health insurance |
Q |
|
| Disease management program |
Q |
|
| Fasting status |
Q |
|
| Birth weight |
Q* |
|
| Anthropometry |
Systolic and diastolic blood pressure |
P |
| Heart rate |
P |
|
| Height |
P |
|
| Weight |
P |
|
| |
Waist circumference |
P |
| Hip circumference |
P |
|
| Risk factors |
Diabetes duration |
Q* |
| Hypertension duration |
Q* |
|
| Smoking history |
Q |
|
| Lipid status |
L |
|
| Physical activity |
Q |
|
| Family history of kidney disease |
Q |
|
| Morbidity |
CAD |
Q |
| |
History of CAD (WHO Rose Angina Questionnaire) |
Q |
| |
Myocardial infarction |
Q# |
| |
CABG, PCI, heart valve surgery |
Q# |
| |
PAD and carotid atherosclerosis |
|
| |
History of PAD (Edinburgh Questionnaire) |
Q |
| |
Vascular surgery or percutaneous intervention in peripheral and carotid vessels |
Q# |
| |
Cerebral ischemia |
Q# |
| |
Microangiopathy |
|
| |
History of kidney disease and biopsy results |
Q# |
| |
Kidney function parameters (e.g. eGFR, annual eGFR decline, albuminuria, change in albuminuria over time, dipstick urine proteinuria) |
L |
| |
Time to doubling of serum creatinine |
L§ |
| |
Time to incident renal replacement therapy |
Q#§ |
| |
Diabetic retinopathy requiring laser therapy |
Q# |
| |
History of malignancy |
Q# |
| |
Hospitalisation |
Q#§ |
| Mortality including cause | Q#§ |
CAD: Coronary artery disease. PAD: peripheral artery disease. Q: self-reported information obtained by questionnaire. L: obtained by laboratory analysis of biosamples. P: obtained by physical examination.
* item determined at baseline visit only.
# items validated by obtaining medical records.
§ item determined at follow-up visits only.