Table 2. Summary of the odds ratios of all toxicities outcomes assessed.

Outcomes	Included studies	OR and 95% CI	P value	Heterogeneity(%)	P value for heterogeneity
Major cardiovascular events	12	1.00 (0.96–1.03)	0.79	0	0.59
Myocardial infarction	12	0.98 (0.92–1.04)	0.54	28	0.17
Stroke	10	0.99 (0.93–1.05)	0.65	0	0.86
Total death	13	1.03 (0.98–1.07)	0.22	33	0.12
Cardiac death	12	1.02 (0.97–1.07)	0.50	4	0.40
Revascularization	4	1.00 (0.95–1.05)	0.97	18	0.30
Total CHD	2	0.96 (0.87–1.05)	0.35	0	0.78
Angina	2	0.98 (0.90–1.07)	0.66	34	0.22
Congestive heart failure	3	1.07 (0.96–1.19)	0.21	15	0.31