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. 2013 Feb 20;8(2):e56841. doi: 10.1371/journal.pone.0056841

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© 2013 Dörner et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The instrumentive surgery of the left anterior descending coronary artery (LAD-Instrumentation) was performed seven days prior to the acute myocardial infarction and reperfusion (AMI/R) to avoid a pro-inflammatory influence of trauma on post-infarction remodelling (PIR). The treatment group received UMS four days after AMI/R. On day +4 and +14, a reconstructive 3-dimensional echocardiography (r3DE) was performed to quantify global and regional left-ventricular function. Additionally, r3DE was carried out with low-dose dobutamine on day +14. Ultimately, hearts were harvested for histological workup.