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. 2013 Feb 20;8(2):e56841. doi: 10.1371/journal.pone.0056841

Figure 2. Therapeutic imaging probe system (TIPS) for ultrasound mediated stimulation of microbubbles.

Figure 2

(A) Hybrid ultrasound probe system with electromechanically coupled diagnostic (+) and therapeutic probe (*) enabling simultaneous high-resolution imaging for targeted application of UMS. To allow a standardized application to a small, moving target organ, the system is coupled to a computer-programmed stepper motor (#). (B) “En face” heart model to visualize the computer-programmed grid on the anterolateral heart wall. The grid consists of 25 pulses total, administered every 1 mm and 5 pulses per row, respectively starting basal (S) and following the white line to the apex till E (end). UMS was targeted on the anterior left-ventricular wall and the anterior borderzone tissue (area within the dotted circle) after anterolateral ischemia. (C)+(D) Ultrasound B-Mode (upper image) and M-Mode (lower image) short axis view before (C) and after (D) microbubble application in a mouse without myocardial infarction. Hence, this hybrid scanhead allows standardized and targeted myocardial delivery of UMS in mice.