Table 5. Allelic association results of replication study and comparison with discovery data.
Gene | SNP(Minor/Major Allele) | Phase of study | MAFb | OR (95% CI) | P-value |
MSH3 | rs12515548(A/G) | Replication | 0.097 | 4.424 (1.572–12.45) | 4.84E-03# |
Discovery | 0.096 | 2.231 (1.666–2.988) | 1.43E-05* | ||
XRCC5 | rs207943(C/G) | Replication | 0.363 | 1.065 (0.474–2.392) | 0.8796# |
Discovery | 0.364 | 1.734 (1.412–2.129) | 1.43E-05* |
MAF: Minor allele frequency of the reference population is listed;
Benjamini-Hochberg False Discovery Rate corrected P-values for multiple tests;
Unadjusted P-values.