Table 1. Main effects of age, treatment and age X treatment interaction on dendritic architecture.

DENDRITIC SPINE DENSITY	MPC Apical	MPC Basal	OPC Basal	PAR1 Apical	PAR1 Basal	NAc Core (Radially Symmetric)	DG (Unipolar, Adult Only)
Age Effect	F(1,26) = 72.08; p<0.001	F(1,26) = 94.547; p<0.001	F(1,26) = 1.235; p = 0.277	F(1,26) = 97.5; p<0.001	F(1,26) = 161.7; p<0.001	F(1,26) = 29.451 p<0.001	NA
Treatment Effect	F(1,26) = 99.16; p<0.001	F(1,26) = 42.219; p<0.001	F(1,26) = 9.58; p = 0.005	F(1,26) = 3.27; p = 0.082	F(1,26) = 2.81; p = 0.106	F(1,26) = 3.595; p = 0.069	F(1,17) = 4.421; p<0.001
Age X Treatment Interaction	F(1,26) = 108.28; p<0.001	F(1,26) = 120.190; p<0.001	F(1,26) = 40.6; p<0.001	F(1,26) = 3.27; p = 0.087	F(1,26) = 2.70; p = 0.113	F(1,26) = 3.267; p = 0.082	NA
TOTAL DENDRITIC LENGTH	MPC Apical	MPC Basal	OPC Basal	PAR1 Apical	PAR1 Basal	NAc Core (Radially Symmetric)	DG (Unipolar)
Age Effect	F(1,26) = 48.47; p<0.001	F(1,26) = 499.04; p<0.001	F(1,26) = 1.441; p = 0.241	F(1,26) = 0.245; p = 0.625	F(1,26) = 17.89; p<0.001	F(1,26) = 16.7; p<0.001	F(1,26) = 94.778; p<0.001
Treatment Effect	F(1,26) = 1.35; p = 0.25	F(1,26) = 1.71; p = 0.202	F(1,26) = 2.35; p = 0.137	F(1,26) = 0.337; p = 0.567	F(1,26) = 0.049; p = 0.826	F(1,26) = 0.401; p = 0.532	F(1,26) = 0.372; p = 0.547
Age X Treatment Interaction	F(1,26) = 0.001; p = 0.97	F(1,26) = 7.36; p = 0.012	F(1,26) = 6.66; p = 0.016	F(1,26) = 0.002; p = 0.960	F(1,26) = 0.578; p = 0.454	F(1,26) = 0.856; p = 0.363	F(1,26) = 3.428; p = 0.075

Cells in bold contain statistically significant effects. In the NAc core and dentate gyrus, neurons are radially symmetric and unipolar, respectively, so there is no distinction of apical and basal dendrites. ‘ND’ indicates statistics based on measures that were not determined in the DG for technical reasons.