Table 2. Finemapping of the 9q34 linkage peak region with microsatellite markers.
Marker | Physicallocus (bp) | Candidategenes | Mouse GASgenesa |
130026756–130155828 | Garnl3 ↓ | ||
130882972–130890712 | Ptges2 ↑ | ||
D9S918 | 130457260 | ||
130500596–130541048 | Sh2d3c ↑ | ||
D9S1827 | 131001749 | ||
D9S290* | 131527468 | ||
131873228–131911225 | Ppp2r4 ↓ | ||
D9S752* | 131951047 | ||
D9S972* | 132051085 | ||
D9S65* | 132190620 | ||
D9S115* | 132248174 | ||
D9S1795* | 132306492 | ||
D9S159* | 132369694 | ||
D9S1831* | 132421728 | ||
132427920–132484953 | PRRX2 | ||
D9S62* | 132461670 | ||
132500615–132515344 | PTGES | Ptges ↑ | |
D9S1861* | 133370746 | ||
D9S118* | 133419164 | ||
D9S1863* | 133499845 | ||
133589268–133763062 | ABL1 | ||
133777825–133814455 | FIBCD1 | ||
133884504–133968446 | LAMC3 | ||
D9S313* | 133887414 | ||
D9S903* | 133935886 | ||
D9S64* | 134380110 | ||
D9S179* | 135091628 | ||
D9S1847* | 135436949 | ||
D9S1830* | 135715761 | ||
D9S1199* | 135831155 | ||
D9S2157 | 136035489 | ||
139743256–139745490 | Phpt1 ↓ | ||
139756571–139760738 | Edf1 ↓ | ||
139942553–139948505 | Entpd2 ↓ | ||
140069236–140083057 | Anapc2 ↑ |
The linkage area is marked by asterisks and the highest linkage peaks are highlighted in bold.
Genes in the mouse quantitative trait locus for susceptibility to group A streptococcal (GAS) infections on chromosome 2 [18]. (↑) Genes up regulated and, (↓) down regulated in GAS susceptible mouse strains.