Table 2. Results of clinical laboratory tests and placental pathology for preterm birth cases.
Variables | Group 1 | Group 2 | Group 3 | Group 4 | P value |
Culture-positive EONS (n = 6) | Presumed EONS & Yes IAI (n = 16) | Presumed EONS & No IAI (n = 7) | No EONS & No IAI (n = 7) | ||
Amniotic fluid | |||||
Glucose ≤15 mg/dL†LDH activity ≥419 IU/L†WBC count ≥30 cells/µL†Positive Gram stain †Positive cultures † | 3 (50)4 (67)4 (67)4 (67)5 (83) | 16 (100)16 (100)16 (100)13 (81)16 (100) | 4 (57)2 (29)2 (29)0 (0)0 (0) | 0 (0)0 (0)0 (0)0 (0)0 (0) | <0.001<0.001<0.001<0.001<0.001 |
Placental pathology | |||||
HCA, stages II or III †Funisitis, grades 1–4 † | 6 (100)3 (50) | 15 (94)11 (69) | 5 (71)4 (57) | 1 (14)0 (0) | <0.001<0.001 |
Neonatal hematology | |||||
ANC, cells/mL *ABC, cells/mL *I:T ratio, % *Platelets, cells/mLx1,000 * | 489 [114–4,201]343[0–1256]10 [0–22]179 [171–267] | 5,491 [2,086–8,632]2,876 [2456–4126]21 [14]–[30]232 [132–320] | 2,592 [2,100–5,974]2,560 [82–4063]17 [1]–[20]209 [70–239] | 3,388 [2,790–5,796]310[116–702]2 [2]–[8]217 [209–292] | 0.106<0.0010.0080.615 |
Data presented as median [interquartile range] and analyzed by Kruskal-Wallis ANOVA.
Data presented as n (%) and analyzed by Chi square.
Abbreviations: EONS, early-onset neonatal sepsis; IAI, intra-amniotic infection; LDH, lactate dehydrogenase; WBC, white blood cell; HCA, histological chorioamnionitis; ANC, absolute neutrophil count; ABC, absolute band count; I:T ratio, ratio of immature-to-total neutrophils.