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. 2013 Feb 20;8(2):e55839. doi: 10.1371/journal.pone.0055839

Figure 7. KRS and KGS inhibited the expression of proinflammatory mediators in tMCAO rats.

Figure 7

(A) Representative photomicrographs of the immunohistochemical expression of iNOS, MMP9, MPO, ICAM, TNF-α, and IL-1β (brown staining) in the cortical ischemic penumbra. (B, C) Immunoreactivity of proinflammatory mediators measured using the integrated optical density (IOD) of the immunostained-positive cells. The data are expressed as mean ± SEM (n  = 6 each group). Treatment with KRS and KGS significantly reduced the expression of proinflammatory mediators. *p<0.05, **p<0.01, compared with the vehicle-treated group.