Table 1. Estimates of parameters (mean ± s.d. over the population) of Eqs. (1)-(2) used to fit IPITT data.
CM proteins | Control n = 23 | Swiss 15 µg n = 11 | Swiss 150 µg n = 7 | db/db 15 µg n = 10 | db/db 150 µg n = 11 |
SG (min−1)×102 | 2.61±0.43 | 2.95±1.04 | 2.15±1.63 | 2.20±0.34 | 1.01±0.75# *° |
SI (min−1⋅pM−1)×105 | 8.45±1.95 | 8.73±4.55 | 9.51±3.50 | 4.50±1.52?× | 5.42±1.22&° |
Gb (mg⋅dl−1) | 156.9±38.6 | 152.2±21.6 | 145.4±12.7 | 223.0±59.9+ | 224.5±46.0+ |
p (min−1)×102 | 1.77±1.22 | 1.47±0.40 | 2.32±1.56 | 3.01±1.32 | 2.93±1.43 |
P<0.001, db/db 150 µg vs. control and Swiss 15 µg;
P<0.005, db/db 15 or 150 µg vs. Swiss 15 or 150 µg;
?P<0.005, db/db 15 µg vs. control;
P<0.01, db/db 15 µg vs. Swiss 15 and 150 µg;
P<0.05, db/db 15 vs. db/db 150 µg;
°P<0.05, db/db 150 µg vs. Swiss 150 µg;
P<0.05, db/db 150 µg vs. control and Swiss 15 µg.