Table 1. Ocular surface autoimmune diseases.

Ocular surface autoimmune disease	Target tissue	Immunopathological features
Localized disease
Dry Eye	Ocular surface epithelium	Increased proinflammatory cytokines (e.g., IL- 1β, TNF-α, IL-17, IFN-γ); CD4+ T-cell infiltration within the conjunctiva; goblet cell loss; squamous metaplasia
Mooren's ulcerative keratitis	Corneal and conjunctival epithelium, Sclera	Infiltration of neutrophils, plasma cells, lymphocytes, and eosinophils
Systemic autoimmunity
Sjogren's syndrome	Primary: lacrimal gland, ocular surface goblet cells	CD4+ T-cell and B-cell infiltration, autoantibodies; goblet cell loss; squamous metaplasia
	Secondary: similar features associated with example rheumatoid arthritis
Ocular cicatricial pemphigoid	Basement membrane of epithelium	Autoantibody and complement deposition in basement membrane of the conjunctiva; macrophages and B cells in the stroma; fibrosis and scarring
Stevens–Johnson syndrome	Epithelium: mucosa and skin	T-cell infiltration (CD4+, CD8+), NK cells; epithelial cell apoptosis; fibrosis; scarring; opacification of the cornea
Systemic autoimmunity following allograft
Graft vs. host disease	Skin, mucous membranes, eye (e.g., conjunctiva, lacrimal gland)	T-cell infiltration; ocular surface manifestations include Dry Eye, KCS, pseudomembranous conjunctivitis, conjunctival fibrosis, lacrimal, and meibomian gland disease, corneal epithelial sloughing

Abbreviations: IFN, interferon; IL, interleukin; KCS, keratoconjunctivitis sicca; TNF, tumor necrosis factor.