Table 1.

The 5- and 10-Year Estimates of Efficacy End Points

End Point	RT + Induction Chemotherapy		RT + Concomitant Chemotherapy		RT Alone
	Estimate (%)	95% CI (%)	Estimate (%)	95% CI (%)	Estimate (%)	95% CI (%)
Laryngectomy-free survival
5 years	44.1	36.6 to 51.6	47.0	39.5 to 54.5	34.0	26.8 to 41.3
10 years	28.9	21.9 to 36.0	23.5	16.8 to 30.3	17.2	11.2 to 23.3
Larynx preservation
5 years	70.8	63.9 to 77.6	83.6	78.1 to 89.2	65.8	58.7 to 73.0
10 years	67.5	60.4 to 74.6	81.7	75.9 to 87.6	63.8	56.5 to 71.1
Local control
5 years	58.2	50.8 to 65.6	71.1	64.3 to 77.9	53.6	46.1 to 61.1
10 years	53.7	46.1 to 61.2	69.2	62.3 to 76.1	50.1	42.5 to 57.7
Locoregional control
5 years	54.8	47.3 to 62.3	67.7	60.7 to 74.7	51.2	43.7 to 58.8
10 years	48.9	41.3 to 56.5	65.3	58.1 to 72.4	47.2	39.6 to 54.8
Distant control
5 years	85.3	79.9 to 90.6	86.4	81.2 to 91.6	78.0	71.7 to 84.3
10 years	83.4	77.7 to 89.0	83.9	78.2 to 89.5	76.0	69.4 to 82.5
Disease-free survival
5 years	37.7	30.4 to 45.0	38.0	30.8 to 45.3	28.0	21.1 to 34.8
10 years	20.4	14.0 to 26.7	21.6	15.2 to 28.0	14.8	9.2 to 20.3
Overall survival
5 years	58.1	50.6 to 65.5	55.1	47.6 to 62.6	53.8	46.1 to 61.4
10 years	38.8	31.2 to 46.3	27.5	20.4 to 34.5	31.5	24.1 to 39.0

Abbreviation: RT, radiation therapy.