Table 4.

ROB for Included Studies by Symptom: Hot Flashes, Fatigue, Mood Disorders, and Sleep Disturbance

Study	Sequence Generation	Allocation Concealment	Blinding	Incomplete Outcome Data	Selective Outcome Reporting	Other Sources of Bias	Level of Risk/Conclusions
Hot flashes
Nedstrand 2006 (see anxiety/depression/mood disorder)49*	+	+	−	+	+	−	H/P
Deng 200750	+	+	+	+	+	0	U/?
Frisk 200851	+	+	−	+	+	−	H/N
Hervik 200925	+	+	+	+	+	0	U/P
Liljegren 201026	+	+	−	+	+	0	H/P
Walker 2010 (see anxiety/depression/mood disorder)52*	+	0	−	+	−	−	H/P
Frisk 2011 (see sleep, anxiety/depression/mood disorder)53*	+	+	−	+	+	−	H/P
Fatigue
Molassiotis 200754	+	+	+	+	+	−	H/P
Balk 2009 (see anxiety/depression/mood disorder)55*	+	+	+	0	+	−	H/N
Johnston 201156	+	+	−	+	+	−	H/N
Anxiety/depression/mood disorder
Nedstrand 2006 (see hot flashes)49	+	+	−	+	+	−	H/P
Mehling 2007 (see pain, nausea in Table 3)33	+	+	−	0	0	−	H/P
Balk 2009 (see fatigue)55	+	+	+	0	+	−	H/N
Walker 2010 (see hot flashes)52	0	0	−	+	−	−	H/P
Feng 2011 (see sleep disturbance)57*	+	0	−	−	+	0	H/P
Sleep disturbance
Cui 200358	0	0	−	0	0	−	H/P
Frisk 2011 (see hot flashes, anxiety/depression/mood disorder)53	+	+	−	+	+	−	H/P
Feng 2011 (see anxiety/depression/mood disorder)57	+	0	−	−	+	0	H/P

NOTE. 0 represents unclear ROB, − represents high ROB, and + represents low ROB.

Abbreviations: H, high ROB for one or more domains; N, conclusions negative for symptoms; P, conclusions positive for symptoms; ROB, risk of bias; U, unclear ROB for one or more domains; ?, conclusions unclear for symptoms.

^*Indicates primary outcome if multiple symptoms were evaluated.