Table 3.
Solid-phase Suzuki feasibility studies
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|---|---|---|---|---|---|---|---|---|---|
| entry | SM | catalyst | base | T(°C) | solvent | product | conv (%)a | SM (%)a | byproduct (%)a |
| 1 | 20 | PdCl2(PPh2)3 | TEA | 60 | EtOH | 22 | 60 | 12 | 18 |
| 2 | 20 | Pd(dba)2, P(t-Bu)3 | K3PO4 | 60 | PhMe | 22 | 70 | 5 | 25 |
| 3 | 20 | PEPPSI | CsCO3 | 60 | 1,4 dioxane | 22 | 78 | 9 | 13 |
| 4 | 20 | Pd(dba)2, S-Phos | K3PO4 | 60 | PhMe | 22 | 73 | 0 | 27 |
| 5 | 20 | Buchwald precatalyst | K3PO4 | rt | THF | 22 | 100 | 0 | 0 |
| 6 | 21 | Buchwald precatalyst | K3PO4 | rt | THF | 23 | 100 | 0 | 0 |
Conversion was measured by UPLC with UV detection at 210 nm.

