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. Author manuscript; available in PMC: 2014 Mar 11.
Published in final edited form as: J Mol Biol. 2012 Dec 26;425(5):886–901. doi: 10.1016/j.jmb.2012.12.011

Figure 2. Aer2 is a novel heme-binding PAS domain that forms a parallel PAS dimer.

Figure 2

(A) Structural alignment of the heme-binding PAS domains of Aer2 (yellow, pdb 4HI4), FixL (purple, pdb 1D06), and EcDOS (pink, pdb 1V9Z). Aer2 conserves the core β– sheet (left) but adopts a novel conformation between the Cα helix and Gβ strand elements (middle and right) to bind heme in a unique way. (B) The ferric Aer2 PAS domain forms a parallel dimer with the Ncap and β sheet at the interface. FixL and EcDOS form similar parallel dimers but with different orientations of the PAS domains.