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Comparison of the r1 of CA-9 and various polyfunctional MRI CAs reported in the literature.
| Contrast Agents | per Gd r1 (mM−1s−1) | Gd3+/molecule | Molar relaxivity |
|---|---|---|---|
| Omniscan® (7T) | 4.2 | 1 | 4.2 |
| CA-9 (7T) | 13.8 (±0.49) | 12 | 155.9† |
| [11a]Cyclodextrin-(DTTA)7 (9.4T) | 6.2 | 7 | 43.4 |
| [11b]Cyclodextrin-(DOTA)7 (1.4T) | 12.2 (±0.54) | 7 | 85.4 |
| [15b]Metallostar-(DTTA)6 (9.4T) | 8.5 | 6 | - |
Molar relaxivity is based on the actual number of Gd per closomer (~11.3) determined from an ICP-OES analysis.
