Table 7.
ligand | oxidant | product | T (°C) | time (h) | d.r. | yield (%) | ee(%) |
---|---|---|---|---|---|---|---|
8a | TBHP | 0 | 10 | 94:6 | 52 | 95 | |
8a | TBHP | 0 | 12 | 95:5 | 60 | 95 | |
8a | TBHP | −10 | 96 | 99:1 | 62 | 95 | |
8b | TBHP | −10 | 96 | 87:13 | 73 | 97 | |
8e | TBHP | 0 | 24 | 98:2 | 52 | 95 | |
8e | CHP | 0 | 120 | 92:8 | 51 | 97 | |
8e | CHP | 0 | 96 | 97:3 | 69 | 97 | |
8e | CHP | 0 | 96 | 60:40 | 40 | 17, 23 |